Infection of humans with Helicobacter pylori produces a chronic gastritis that in some people can lead to the development of peptic ulcers, Mucosal-Associated Lymphoid Tissue (MALT) lymphoma and gastric adenocarcinoma
Infection of humans with Helicobacter pylori produces a chronic gastritis that in some people can lead to the development of peptic ulcers, Mucosal-Associated Lymphoid Tissue (MALT) lymphoma and gastric adenocarcinoma. Some infected individuals develop serious pathologies while most remain asymptomatic due to a variety of different factors, including bacterial strain variation and diet. Another key factor is host genetics which may, for example, influence the immune response mounted against infection.
Infection of the majority of mice with Helicobacter also produces chronic gastritis. We have developed a model of Helicobacter infection where mice do not develop gastritis and this trait is dominantly inherited in offspring. Using this model we are studying the types of immune cells and mucosal mechanisms that regulate inappropriate immune responses to gastrointestinal infections and that are involved in the induction of immune tolerance
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